Investigation by the Ames test of urine samples from rats exposed to methyl isocyanate.
نویسندگان
چکیده
منابع مشابه
Functional evidence of persistent airway obstruction in rats following a two-hour inhalation exposure to methyl isocyanate.
Pulmonary function was assessed in male, F344 rats 1,2,4,7, and 13 weeks after a single 2-hr exposure to 0, 3, 10, or 30 ppm methyl isocyanate. No significant changes were observed in the rats exposed to 3 ppm through 13 weeks. Diffusing capacity (DLco), quasistatic lung compliance, and homogeneity of ventilation, as determined by multibreath nitrogen washout, were depressed in the rats exposed...
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متن کاملToxicity of inhaled methyl isocyanate in F344/N rats and B6C3F1 mice. I. Acute exposure and recovery studies.
Male and female F344/N rats and B6C3F1 mice were exposed to lethal and sublethal concentrations of methyl isocyanate by inhalation. Mortality, clinical signs, body and organ weights, and changes in clinical pathology and hematology were monitored immediately after 2-hr exposures and during the ensuing 3 months. Additional studies investigated the possible involvement of cyanide in the toxicity ...
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ورودعنوان ژورنال:
- British journal of industrial medicine
دوره 43 8 شماره
صفحات -
تاریخ انتشار 1986